Skip to Content

Purified clinoptilolite-tuff


Purified Clinoptilolite-Tuff as a Trap for Amines Associated with Chronic Wounds: Binding of Cadaverine, Putrescine, Histamines and Polyamines

The research paper investigates the potential of purified clinoptilolite-tuff (PCT) as a binding agent for amines associated with chronic wounds, particularly focusing on cadaverine, putrescine, histamines, and polyamines. Chronic wounds, especially malignant fungating wounds, are challenging to manage due to their associated malodor, primarily caused by bacterial breakdown products like cadaverine and putrescine. The study demonstrates that PCT can effectively bind these compounds, with binding occurring rapidly and exhibiting high capacity and stability even in the presence of competing ligands found in wound drainage fluids.

Using radiolabeled tracers, the researchers found that PCT binds cadaverine, histamine, spermidine, and spermine with affinities in the low micromolar range. The binding sites were shown to be non-equivalent, indicating a complex interaction with the ligands. Displacement experiments revealed that the binding of histamine and spermidine to PCT was influenced by the presence of other amines, with varying degrees of potency observed among the competing ligands.

The study further explored the binding capacity of PCT when incorporated into a wound dressing, confirming that the dressing maintained its ability to adsorb cadaverine effectively. The authors propose that PCT could be a valuable tool in managing malodor from chronic wounds, suggesting further investigation into its clinical applications.


This research paper is significant in the field of wound care and pharmacology as it addresses a critical issue in the management of chronic wounds—malodor, which can lead to social isolation and distress for patients. The findings contribute to ongoing discussions about innovative wound management strategies, particularly in palliative care settings. By demonstrating the efficacy of PCT in binding odor-causing amines, the research offers a potential alternative to existing treatments, which often have limited effectiveness. The incorporation of PCT into wound dressings could enhance patient comfort and improve the quality of life for those suffering from chronic wounds. Additionally, the study opens avenues for future research into the broader applications of clinoptilolite in wound care and its potential to mitigate bacterial growth and associated complications.

Read Original Paper